Conditional Hardness of Earth Mover Distance

The Earth Mover Distance (EMD) between two sets of points A, B subseteq R^d with |A| = |B| is the minimum total Euclidean distance of any perfect matching between A and B. One of its generalizations is asymmetric EMD, which is the minimum total Euclidean distance of any matching of size |A| between sets of points A,B subseteq R^d with |A| <= |B|. The problems of computing EMD and asymmetric EMD are well-studied and have many applications in computer science, some of which also ask for the EMD-optimal matching itself. Unfortunately, all known algorithms require at least quadratic time to compute EMD exactly. Approximation algorithms with nearly linear time complexity in n are known (even for finding approximately optimal matchings), but suffer from exponential dependence on the dimension. In this paper we show that significant improvements in exact and approximate algorithms for EMD would contradict conjectures in fine-grained complexity. In particular, we prove the following results: - Under the Orthogonal Vectors Conjecture, there is some c>0 such that EMD in Omega(c^{log^* n}) dimensions cannot be computed in truly subquadratic time. - Under the Hitting Set Conjecture, for every delta>0, no truly subquadratic time algorithm can find a (1 + 1/n^delta)-approximate EMD matching in omega(log n) dimensions. - Under the Hitting Set Conjecture, for every eta = 1/omega(log n), no truly subquadratic time algorithm can find a (1 + eta)-approximate asymmetric EMD matching in omega(log n) dimensions

Research Report

The aim of this research report is to examine the empirical literature on the connection between the legitimacy of governance actors and conflict prevention. As the leading hypothesis for this research report, we take it that legitimate governance actors and legitimate institutions are indispensable in the prevention of conflict. We proceed with our examination of this hypothesis in two steps. First, we clarify the conceptual connection between legitimacy and conflict prevention. We suggest that governance actors should concentrate less on stability and more on legitimacy because legitimate actors and institutions produce stability for the right reasons. Second, we discuss the practical implications of these considerations. Our findings are relevant both for narrow, project-based external policy initiatives in the field of conflict prevention and for more general governance interventions. In both cases, policies can focus on two dimensions. First, improving governance performance will include adjusting external policies to fit local legitimacy perceptions. The second dimension is the transformation of predominant perceptions of legitimacy. We argue that while the second strategy might not be impossible, it is not a viable strategy for external actors. In fact, we believe that the focus on this second dimension explains many of the unsuccessful attempts at governance provision by external actors.In der vorliegenden Studie untersuchen wir den Zusammenhang zwischen der Prävention von Konflikten und der Legitimität von Governance-Akteuren. Uns leitet die Hypothese, dass legitime Governance-Akteure und legitime Institutionen für die Konfliktprävention unabdingbar sind. Wir gehen dabei in zwei Schritten vor: zunächst klären wir den genannten Zusammenhang auf der konzeptuellen Ebene. Unser Vorschlag lautet, dass sich Governance- Akteure weniger auf Stabilität, und mehr auf Legitimität konzentrieren sollten, da legitime Akteure und Institutionen Stabilität aus den normativ richtigen Gründen erzeugen. Im zweiten Schritt diskutieren wir die Implikationen unserer Überlegungen für die praktische Umsetzung. Unsere Ergebnisse sind dabei sowohl für enge, projektbasierte externe Policy- Initiativen, als auch für breiter angelegte Governance-Interventionen von Bedeutung. In beiden Fällen können Initiativen an zwei Dimensionen andocken: erstens kann die performance- Dimension von Governance verbessert werden, indem die externen Policy- Initiativen den lokalen Legitimitätsvorstellungen angepasst werden. Zweitens kann auf der konzeptuellen Ebene angesetzt werden, indem lokale Legitimitätsvorstellungen verändert werden. Während diese zweite Strategie nicht unmöglich scheint, sind wir davon überzeugt, dass ihre Effektivität sehr begrenzt ist. In den meisten Fällen sind Versuche, die externen Legitimitätsüberzeugungen auf die betroffenen Bevölkerung anzuwenden, zum Scheitern verurteilt

Bichromatic phase-control of interfering Autler-Townes spectra

We propose a new scheme to control the shape of the Autler-Townes (AT) doublet in the photoelectron spectrum from atomic resonance-enhanced multiphoton ionization (REMPI). The scheme is based on the interference of two AT doublets created by ionization of the strongly driven atom from the ground and the resonantly excited state using tailored bichromatic femtosecond (fs) laser pulses. In this scheme, the quantum phase of the photoelectrons is crucial for the manipulation of the AT doublet. The laser polarization state and the relative optical phase between the two colors are used to manipulate the interference pattern. We develop an analytical model to describe the bichromatic REMPI process and provide a physical picture of the control mechanism. To validate the model, the results are compared to an ab initio calculation based on the solution of the 2D time-dependent Schr\"odinger equation for the non-perturbative interaction of an atom with intense polarization-shaped bichromatic fs-laser pulses. Our results indicate that the control mechanism is robust with respect to the laser intensity facilitating its experimental observation.Comment: 13 pages, 5 figure

Immune responses to gp82 provide protection against mucosal Trypanosoma cruzi infection

The potential use of the Trypanosoma cruzi metacyclic trypomastigote (MT) stage-specific molecule glycoprotein-82 (gp82) as a vaccine target has not been fully explored. We show that the opsonization of T. cruzi MT with gp82-specific antibody prior to mucosal challenge significantly reduces parasite infectivity. In addition, we investigated the immune responses as well as the systemic and mucosal protective immunity induced by intranasal CpG-adjuvanted gp82 vaccination. Spleen cells from mice immunized with CpG-gp82 proliferated and secreted IFN-γ in a dose-dependent manner in response to in vitro stimulation with gp82 and parasite lysate. More importantly, these CpG-gp82-immunized mice were significantly protected from a biologically relevant oral parasite challenge.Saint Louis University Department of Molecular MicrobiologyUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Microbiologia, Imunologia e ParasitologiaUNIFESP, EPM, Depto. de Microbiologia, Imunologia e ParasitologiaSciEL

Late Proterozoic Patsy Springs Canyon, Adelaide Geosyncline: Submarine or Subaerial Origin?

A significant aspect of Late Proterozoic sedimentation in the Adelaide Geosyncline, South Australia, is the presence of kilometre-deep erosional incisions which have been termed canyons. These structures were formerly described to be of submarine origin, cut and filled in an inferred basin-slope setting by subaqueous processes. Subsequent detailed research, particularly on a specific incision known as Patsy Springs Canyon, indicates that sedimentary structures within some of the canyon-filling sediments are indicative of deposition above fair weather wave base. In addition, an unusual carbonate unit, which is observed to veneer upper portions of canyon shoulders and to contribute to carbonate breccias interbedded with canyon-fill, has a stable isotope signature which may imply a non-marine origin. The presence of the carbonate veneer, where it is in situ, suggests that at least upper portions of the canyons could have been emergent during the canyon-filling phase. Considering these observations, and combining them with regional stratigraphical relationships, an alternative model for canyon genesis is proposed involving subaerial erosion and subsequent filling by coastal onlap. Such a model requires base-level changes of the order of 1 km, in order to account for observed canyon cutting and filling. Vertical movements associated with halokinesis, or thermally-induced uplift of the order of 1 km, could have resulted in the observed erosional events. Alternatively, a Messinian-style evaporitic lowering of base-level is currently receiving serious attention. With present knowledge this mechanism most satisfactorily explains all observations

Orbital angular momentum superposition states in transmission electron microscopy and bichromatic multiphoton ionization

The coherent control of electron beams and ultrafast electron wave packets dynamics have attracted significant attention in electron microscopy as well as in atomic physics. In order to unify the conceptual pictures developed in both fields, we demonstrate the generation and manipulation of tailored electron orbital angular momentum (OAM) superposition states either by employing customized holographic diffraction masks in a transmission electron microscope or by atomic multiphoton ionization utilizing pulse-shaper generated carrier-envelope phase stable bichromatic ultrashort laser pulses. Both techniques follow similar physical mechanisms based on Fourier synthesis of quantum mechanical superposition states allowing the preparation of a broad set of electron states with uncommon symmetries. We describe both approaches in a unified picture based on an advanced spatial and spectral double slit and point out important analogies. In addition, we analyze the topological charge and discuss the control mechanisms of the free-electron OAM superposition states. Their generation and manipulation by phase tailoring in transmission electron microscopy and atomic multiphoton ionization is illustrated on a 7-fold rotationally symmetric electron density distribution.Comment: K. Eickhoff and C. Rathje contributed equally to this wor

Immunohistochemical detection of macrophage migration inhibitory factor in fetal and adult bovine epididymis: Release by the apocrine secretion mode?

Originally defined as a lymphokine inhibiting the random migration of macrophages, the macrophage migration inhibitory factor (MIF) is an important mediator of the host response to infection. Beyond its function as a classical cytokine, MIF is currently portrayed as a multifunctional protein with growth-regulating properties present in organ systems beyond immune cells. In previous studies, we detected substantial amounts of MIF in the rat epididymis and epididymal spermatozoa, where it appears to play a role during post-testicular sperm maturation and the acquisition of fertilization ability. To explore its presence in other species not yet examined in this respect, we extended the range of studies to the bull. Using a polyclonal antibody raised against MIF purified from bovine eye lenses, we detected MIF in the epithelium of the adult bovine epididymis with the basal cells representing a prominently stained cell type. A distinct accumulation of MIF at the apical cell pole of the epithelial cells and in membranous vesicles localized in the lumen of the epididynnal duct was obvious. In the fetal bovine epididymis, we also detected MIF in the epithelium, whereas MIF accumulation was evident at the apical cell surface and in apical protrusions. By immuno-electron microscopy of the adult bovine epididymis, we localized MIF in apical protrusions of the epithelial cells and in luminal membrane-bound vesicles that were found in close proximity to sperm cells. Although the precise origin of the MIF-containing vesicles remains to be delineated, our morphological observations support the hypothesis that they become detached from the apical surface of the epididymal epithelial cells. Additionally, an association of MIF with the outer dense fibers of luminal spermatozoa was demonstrated. Data obtained in this study suggest MIF release by an apocrine secretion mode in the bovine epididymis. Furthermore, MIF localized in the basal cells of the epithelium and in the connective tissue could be responsible for regulating the migration of macrophages in order to avoid contact of immune cells with spermatozoa that carry a wide range of potent antigens. Copyright (c) 2006 S. Karger AG, Basel